PERSPECTIVAS MÉDICAS


Perspect. Med. ISSN 0100-2929

Basic and Clinical Research

Perspectivas Médicas, 26(1): 5-15, jan/abr. 2015
DOI: 10.6006/perspectmed.20150101.56372S1645

 

Autosomal dominant polycystic kidney disease: possible influences of single nucleotide polymorphism in cytokine genes

 
Keywords: autosomal dominant polycystic kidney disease; inflammation; renal insufficiency, chronic; SNPs; cytokines
 

Authors:

Everton Fernando Alves1
Sueli Donizete Borelli2
Luiza Tamie Tsuneto3

1Enfermeiro, Mestre em Ciências da Saúde pela Universidade Estadual de Maringá, Paraná, Brasil
2Professora Doutora do Programa de Pós-graduação em Ciências da Saúde, Laboratório de Imunogenética (LIG-UEM), Universidade Estadual de Maringá, Paraná, Brasil
3Professora Doutora do Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Imunogenética (LIG-UEM), Universidade Estadual de Maringá, Paraná, Brasil


 

Correspondence to:

Luiza Tamie Tsuneto - Laboratório de
Imunogenética - Departamento de Ciências Básicas da Saúde - Universidade Estadual de
Maringá, Paraná, Brasil
e-mail: lttsuneto@uem.br


 
ABSTRACT

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited diseases in adults and is caused by mutations in one of two genes, PKD1 or PKD2, which result in accumulation of cysts in the kidneys that can lead to a loss of function. Is the third leading cause of chronic kidney disease (CKD) stage 5. Inflammation has been considered one of the responsible for the progression of CKD. Cytokines act directly in this process by increasing or decreasing the inflammatory response. The stimulation of these cytokines is associated with variants in cytokine genes. These variants may be factors related to clinical progression of CKD.
Thus, this manuscript aims to present some polymorphic variants in cytokine genes described for kidney and inflammatory diseases and relate them to the predisposition of ADPKD. In addition, understanding this relationship and may contribute with knowledge of etiopatogenicity of the disease and develop strategies in prevention, diagnosis and treatment.

 

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